This document presents WASH UP! Girl Talk program as a promising practice in integrating Gender Equality and Social Inclusion (GESI) to Water, Sanitation and Hygiene (WASH) programming in Zimbabwe. WASH UP! Girl Talk project empowered primary school-aged children (pre-adolescent and adolescent girls and boys) to practice and promote healthy water, sanitation and hygiene behaviors, particularly around menstrual health, and hygiene. The WASH UP! Girl Talk program was implemented in Zimbabwe in 2017-2020 with funding from Dubai Cares Foundation. World Vision partnered with Sesame Workshop to develop contextualized child appropriate multi-media content and educational materials on puberty, healthy body, menstrual cycle, menstrual hygiene management, and girls’ empowerment. The project targeted remote, low-resource communities in rural Zimbabwe.